Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558420 | 0.85 | IGF1R (0.37) | IGF1R | |
| SCHEMBL17558351 | 0.83 | IGF1R (0.42) | IGF1R | |
| SCHEMBL2941160 | 0.82 | IGF1R (0.38) | IGF1RNAMPT | |
| SCHEMBL3736465 | 0.82 | IGF1R (0.38) | IGF1RNAMPT | |
| SCHEMBL3732092 | 0.82 | IGF1R (0.38) | IGF1RNAMPT | |
| SCHEMBL3726823 | 0.82 | IGF1R (0.51) | IGF1RNAMPTLMNAMAPK1HTT | |
| SCHEMBL17558367 | 0.81 | IGF1R (0.34) | IGF1R | |
| SCHEMBL2942410 | 0.72 | IGF1R (0.42) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17558364 | 0.72 | IGF1R (0.40) | IGF1R | |
| SCHEMBL3741410 | 0.71 | IGF1R (0.36) | IGF1RNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |