Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17558348 | 0.88 | TACR1 (0.30) | — | |
| SCHEMBL17558364 | 0.87 | IGF1R (0.40) | IGF1R | |
| SCHEMBL17558355 | 0.81 | IGF1R (0.35) | IGF1R | |
| SCHEMBL3726823 | 0.80 | IGF1R (0.51) | IGF1R | |
| SCHEMBL3723549 | 0.74 | IGF1R (0.36) | IGF1RPTGS1PTGS2 | |
| SCHEMBL17558351 | 0.72 | IGF1R (0.42) | IGF1R | |
| SCHEMBL3730826 | 0.72 | IGF1R (0.46) | IGF1R | |
| SCHEMBL17558420 | 0.67 | IGF1R (0.37) | IGF1R | |
| Trifluoroacetic Acid SCHEMBL17558366 | 0.66 | IGF1R (0.38) | IGF1RPTGS2 | |
| Trifluoroacetic Acid SCHEMBL3723547 | 0.65 | IGF1R (0.46) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |