Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176024 | 0.87 | IGF1R (0.41) | IGF1RNPC1RAB9A | |
| SCHEMBL6206323 | 0.85 | IGF1R (0.37) | IGF1RIDH1 | |
| SCHEMBL6172644 | 0.84 | IGF1R (0.40) | IGF1R | |
| SCHEMBL6173512 | 0.84 | ADRB1 (0.40) | IGF1R | |
| SCHEMBL6173502 | 0.84 | IGF1R (0.38) | IGF1R | |
| SCHEMBL6174968 | 0.83 | ITGB2 (0.39) | IGF1R | |
| SCHEMBL6174595 | 0.83 | IGF1R (0.52) | IGF1R | |
| SCHEMBL6170998 | 0.83 | IGF1R (0.43) | IGF1RNPC1RAB9A | |
| SCHEMBL6174494 | 0.82 | IGF1R (0.42) | IGF1R | |
| SCHEMBL6172820 | 0.82 | IGF1R (0.42) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |