Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 15/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756392 | 0.86 | POLB (0.52) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL17414635 | 0.83 | POLB (0.51) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL1756433 | 0.81 | GYS1 (0.53) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL1756448 | 0.81 | MAPT (0.69) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL1756429 | 0.80 | MAPK1 (0.47) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL2011581 | 0.77 | POLB (0.55) | GYS1POLBL3MBTL1MAPK1MAPT | |
| SCHEMBL2009245 | 0.74 | POLB (0.54) | GYS1POLBL3MBTL1MAPT | |
| SCHEMBL17414642 | 0.72 | POLB (0.48) | GYS1POLBL3MBTL1MAPK1NPC1 | |
| SCHEMBL2011674 | 0.71 | MAPT (0.67) | POLBL3MBTL1MAPK1NPC1MAPT | |
| SCHEMBL17414636 | 0.69 | MAPT (0.48) | GYS1POLBL3MBTL1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058154-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |