SCHEMBL1756490

SCHEMBL1756490

Fc1cc(Cl)c(Cl)c(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.40
ALDH1A1 P00352 3/20 0.38
HPGD P15428 5/20 0.35
HSD17B10 Q99714 5/20 0.35
TSHR P16473 4/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
CASP1 P29466 1/20 0.35
AHR P35869 2/20 0.35
HTR3E A5X5Y0 1/20 0.32
HTR3B O95264 1/20 0.32
HTR3A P46098 1/20 0.32
HTR3D Q70Z44 1/20 0.32
HTR3C Q8WXA8 1/20 0.32
HSP90AA1 P07900 1/20 0.32
MAPK1 P28482 1/20 0.32
KDM1A O60341 2/20 0.31
KDM1B Q8NB78 1/20 0.31
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1756502 0.82 CYP3A4 (0.47) CYP3A4ALDH1A1HPGDHSD17B10TSHR
SCHEMBL9774781 0.82 CYP3A4 (0.40) CYP3A4ALDH1A1HPGDHSD17B10TSHR
SCHEMBL1042005 0.79 KDM1A (0.32) ALDH1A1KDM1AKDM1BCES2CES1
SCHEMBL2930354 0.79 GRIN2D (0.40) CES2CES1GRIN2DGRIN3BGRIN1
SCHEMBL11872648 0.79 CYP3A4 (0.50) CYP3A4ALDH1A1HPGDHSD17B10TSHR
SCHEMBL18167032 0.78
SCHEMBL9643418 0.78 CYP3A4 (0.56) CYP3A4ALDH1A1HPGDHSD17B10TSHR
SCHEMBL11192387 0.77 GRIN2D (0.39) CYP3A4ALDH1A1KDM1AKDM1BGRIN2D
SCHEMBL17219203 0.76 CA1 (0.36) CYP3A4ALDH1A1HPGDHSD17B10TSHR
SCHEMBL18167031 0.74 GRIN2D (0.33) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0905085-B1 Process for the separation of hydrogen fluoride from its mixtures with a hydrofluoroalkane having 3 to 6 carbon atoms SOLVAY (BE) 2007-04-11 EP claimed
US-6294055-B2 EXTRACTING MIXTURE CONTAINING 1,1,1,3,3-PENTAFLUOROBUTANE AND HYDROGEN FLUORIDE WITH SOLVENT UNDER PRESSURE; SEPARATING ORGANIC PHASE ENRICHED IN 1,1,1,3,3-PENTAFLUOROBUTANE FROM PHASE ENRICHED IN HYDROGEN FLUORIDE SOLVAY S.A. (BE) 2001-09-25 US claimed
US-20010004961-A1 PROCESS FOR THE SEPARATION OF HYDROGEN FLUORIDE FROM ITS MIXTURES WITH A HYDROFLUOROALKANE CONTAINING FROM 3 TO 6 CARBON ATOMS SOLVAY (SOCIETE ANONYME) (BE) 2001-06-28 US claimed
EP-0905085-A1 Process for the separation of hydrogen fluoride from its mixtures with a hydrofluoroalkane having 3 to 6 carbon atoms SOLVAY (Société Anonyme) (BE) 1999-03-31 EP claimed
CN-112384851-B Electro-optic display and driving method 伊英克公司 2025-05-20 CN disclosed
CN-112384851-A Electro-optic display and driving method 伊英克加利福尼亚有限责任公司 2021-02-19 CN disclosed
US-7943257-B2 Electrolyte solvent and rechargeable lithium battery SAMSUNG SDI CO., LTD. (KR) 2011-05-17 US disclosed
CN-101441381-B Preparation method of solvent-resistant electronic paper microcups and material for preparing solvent-resistant electronic paper microcups CHINESE ACAD TECH INST PHYSICS 2010-08-04 CN disclosed
CN-101441382-B One-step cover sealing method and cover sealing material for electronic paper micro-cup CHINESE ACAD TECH INST PHYSICS 2010-08-04 CN disclosed
US-20100104949-A1 Electrolyte and rechargeable lithium battery YAMAGUCHI TAKITARO 2010-04-29 US disclosed
CN-101441381-A Preparation method of solvent-resistant electronic paper microcups and material for preparing solvent-resistant electronic paper microcups CHINESE ACAD TECH INST PHYSICS (CN) 2009-05-27 CN disclosed
CN-101441382-A One-step cover sealing method and cover sealing material for electronic paper micro-cup CHINESE ACAD TECH INST PHYSICS (CN) 2009-05-27 CN disclosed
EP-0682008-B1 Substituted 2-chloro-3,4,5-trifluorobenzenes and process for their preparation CLARIANT GMBH (DE) 1998-12-30 EP disclosed
EP-0824096-A2 Process for the preparation of halogenated (meth)acrylic esters and poly (meth) arcylates obtained with said (meth)acrylic esters Akzo Nobel N.V. (NL) 1998-02-18 EP disclosed
US-5565612-A Substituted 2-chloro-3,4,5-trifluorobenzenes and a process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1996-10-15 US disclosed
EP-0682008-A1 Substituted 2-chloro-3,4,5-trifluorobenzenes and process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1995-11-15 EP disclosed
EP-0028161-B1 FLUORINATED PHENOLIC POLYMER AND PROCESS FOR ITS PREPARATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-03-21 EP disclosed
US-4321339-A Fluorinated phenoxypropyl vinyl ether polymer E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-03-23 US disclosed
US-4288574-A POST HYDROXYLATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-08 US disclosed
EP-0028161-A1 Fluorinated phenolic polymer and process for its preparation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-05-06 EP disclosed