Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 2/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15777750 | 0.86 | RAB9A (0.54) | HDAC8MAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL559537 | 0.86 | NOTUM (0.58) | HDAC8MAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL25210452 | 0.81 | FFAR4 (0.59) | MAPTRAB9ALMNAL3MBTL1CYP1A2 | |
| SCHEMBL15776567 | 0.80 | CNR2 (0.55) | MAPTKDM5AKDM5BMRGPRX4KMT2A | |
| SCHEMBL6066763 | 0.79 | HDAC8 (0.54) | HDAC8MAPTRAB9ALMNAHDAC6 | |
| SCHEMBL16930354 | 0.79 | ALDH1A1 (0.53) | HDAC8MAPTLMNAL3MBTL1CYP1A2 | |
| SCHEMBL16055873 | 0.78 | CYP11B1 (0.55) | HDAC8MAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL6418760 | 0.77 | MAOB (0.72) | MAPTRAB9ALMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL23484500 | 0.77 | HDAC8 (0.47) | HDAC8MAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL6066649 | 0.77 | F10 (0.55) | MAPTRAB9ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458129-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458129-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-04 | — | — | US | disclosed |
| US-20160068507-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. | 2016-03-10 | — | — | US | disclosed |
| US-20160068507-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068507-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM5A, KDM1A | HDAC8 44/4885MAPT 2204/4885RAB9A 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.