Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 16/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17570439 | 0.99 | OPRK1 (0.74) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL17570438 | 0.99 | OPRK1 (0.74) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL8061920 | 0.87 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL8061918 | 0.87 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL17570381 | 0.87 | OPRK1 (1.00) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL9450338 | 0.86 | OPRK1 (0.64) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL17570393 | 0.86 | OPRK1 (0.80) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL17570392 | 0.85 | OPRK1 (0.97) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL17105736 | 0.85 | OPRK1 (0.97) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL29543016 | 0.85 | OPRK1 (0.97) | OPRK1CYP2D6CYP3A4TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167295-B2 | Analgesic compounds and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-01-01 | — | — | US | disclosed |
| US-20160068541-A1 | ANALGESIC COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-10 | — | — | US | disclosed |
| US-20160068541-A1 | ANALGESIC COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068541-A1 | ANALGESIC COMPOUNDS AND METHODS OF USE | OPRL1, OPRK1, ACHE | OPRK1 2/4885CYP2D6 140/4885CYP3A4 378/4885 |
| US-10167295-B2 | Analgesic compounds and methods of use | OPRL1, OPRK1, ACHE | OPRK1 2/4885CYP2D6 140/4885CYP3A4 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.