Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 18/20 | 0.55 |
| ▸ | KCNJ3 | P48549 | 18/20 | 0.55 |
| ▸ | KCNJ5 | P48544 | 13/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25793174 | 0.81 | KCNJ6 (0.69) | KCNJ6KCNJ3KCNJ5SMN1; SMN2 | |
| SCHEMBL4513114 | 0.80 | KCNJ6 (0.72) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL23203519 | 0.78 | KCNJ6 (0.65) | KCNJ6KCNJ3KCNJ5NPC1LMNA | |
| SCHEMBL31522194 | 0.77 | NPC1 (0.59) | KCNJ6KCNJ3KCNJ5NPC1LMNA | |
| SCHEMBL13234482 | 0.76 | KCNJ6 (0.84) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL16673760 | 0.75 | KCNJ6 (0.69) | KCNJ6KCNJ3KCNJ5NPC1LMNA | |
| SCHEMBL1010934 | 0.74 | KCNJ6 (0.63) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL20627649 | 0.72 | MAPK13 (0.60) | SMN1; SMN2 | |
| SCHEMBL1011586 | 0.72 | RAB9A (0.88) | KCNJ6KCNJ3KCNJ5NPC1LMNA | |
| SCHEMBL22896928 | 0.72 | ALDH1A1 (0.55) | KCNJ6KCNJ3KCNJ5NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |