Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757257 | 0.90 | HTR6 (0.58) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3650304 | 0.89 | HTR2A (0.47) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580928 | 0.86 | HTR2A (0.50) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580995 | 0.86 | HTR2A (0.49) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL17580734 | 0.84 | HTR2A (0.46) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327046 | 0.83 | HTR6 (0.52) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327062 | 0.82 | HTR6 (0.53) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327083 | 0.82 | NOTUM (0.53) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327032 | 0.82 | NOTUM (0.53) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL19327040 | 0.82 | NOTUM (0.53) | HTR6HTR2AHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185555-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBVIE DEUTSCHLAND (DE) | 2016-03-16 | — | — | EP | claimed |