Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA4 | P22748 | 4/20 | 0.35 |
| ▸ | CA7 | P43166 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757257 | 0.93 | HTR6 (0.58) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3650493 | 0.88 | HTR2A (0.49) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL17580963 | 0.87 | HTR2A (0.51) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL17580979 | 0.86 | HTR6 (0.47) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL17581014 | 0.84 | HTR6 (0.59) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL17580902 | 0.81 | HTR2A (0.47) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3651344 | 0.81 | HTR2A (0.54) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3646817 | 0.80 | HTR6 (0.58) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL3646142 | 0.80 | HTR6 (0.53) | HTR2AHTR6HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL3643522 | 0.80 | HTR6 (0.57) | HTR2AHTR6HTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185555-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBVIE DEUTSCHLAND (DE) | 2016-03-16 | — | — | EP | claimed |