Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethomorph. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethomorph SCHEMBL22863 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| Dimethomorph SCHEMBL29377277 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| Dimethomorph SCHEMBL54189 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| Dimethomorph SCHEMBL676762 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| Dimethomorph SCHEMBL29564213 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| SCHEMBL9367620 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL9364179 | 0.83 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HPGDKMT2AMAPT | |
| Dimethomorph SCHEMBL8773909 | 0.83 | CYP2D6 (0.45) | ALDH1A1SMN1; SMN2HPGDKMT2ACNR1 | |
| Dimethomorph SCHEMBL28278511 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDKMT2AKDM4E | |
| SCHEMBL12920830 | 0.79 | KMT2A (0.61) | ALDH1A1SMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3566579-A2 | FUNGICIDAL COMPOSITION HAVING SYNERGISTIC EFFECT | Jiangsu Huifeng Agrochemical Co., Ltd. (CN) | 2019-11-13 | — | — | EP | disclosed |
| EP-2995200-B1 | STERILIZATION COMPOSITION WITH SYNERGISM | JIANGSU HUIFENG AGROCHEMICAL CO LTD (CN) | 2019-06-05 | — | — | EP | disclosed |
| EP-2995200-A1 | STERILIZATION COMPOSITION WITH SYNERGISM | Jiangsu Huifeng Agrochemical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |