Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethomorph. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethomorph SCHEMBL17581007 | 0.83 | ALDH1A1 (0.46) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL29564213 | 0.82 | SMN1; SMN2 (0.57) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL22863 | 0.82 | SMN1; SMN2 (0.57) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL676762 | 0.82 | SMN1; SMN2 (0.57) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL29377277 | 0.82 | SMN1; SMN2 (0.57) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL54189 | 0.82 | SMN1; SMN2 (0.57) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL9367620 | 0.78 | ALDH1A1 (0.52) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL9364179 | 0.77 | ALDH1A1 (0.64) | KMT2AALDH1A1HPGDSMN1; SMN2 | |
| Dimethomorph SCHEMBL28278511 | 0.76 | ALDH1A1 (0.50) | KMT2AALDH1A1HPGDSMN1; SMN2POLB | |
| Dimethomorph SCHEMBL7199910 | 0.75 | KDM4E (0.40) | CYP2D6CYP2C9ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804284-A1 | MICROENCAPSULATION PROCESS AND PRODUCT | DOWELANCO (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022159-A1 | MICROENCAPSULATION PROCESS AND PRODUCT | DOWELANCO (US) | 1996-07-25 | — | — | WO | disclosed |