Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 15/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 8/20 | 0.54 |
| ▸ | BRD2 | P25440 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17581447 | 0.83 | BRD4 (0.52) | BRD4CREBBPBRD2LMNAALDH1A1 | |
| SCHEMBL5945605 | 0.75 | JAK2 (0.70) | JAK2BRD4CREBBPBRD2CYP2C9 | |
| SCHEMBL17581408 | 0.75 | JAK2 (0.62) | JAK2BRD4BRD2LMNACYP2C9 | |
| SCHEMBL17581450 | 0.74 | JAK2 (0.73) | JAK2BRD4CREBBPLMNACYP2C9 | |
| SCHEMBL17860612 | 0.72 | JAK2 (0.68) | JAK2BRD4CREBBPCYP2C9 | |
| SCHEMBL16731354 | 0.70 | BRD4 (1.00) | BRD4CREBBP | |
| SCHEMBL24096948 | 0.70 | JAK2 (0.66) | JAK2BRD4CREBBPBRD2LMNA | |
| SCHEMBL19069465 | 0.68 | BRD4 (1.00) | BRD4BRD2CYP2C9 | |
| SCHEMBL17758368 | 0.68 | BRD4 (0.68) | BRD4LMNACYP2C9 | |
| SCHEMBL17581420 | 0.67 | JAK2 (0.61) | JAK2BRD4CREBBPBRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856259-B2 | Heterocyclic compounds and uses thereof | PLEXXIKON INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-9856259-B2 | Heterocyclic compounds and uses thereof | PLEXXIKON INC. (US) | 2018-01-02 | — | — | US | disclosed |
| EP-3194392-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Plexxikon, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044067-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PLEXXIKON INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044067-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PLEXXIKON INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20160075712-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PLEXXIKON INC. | 2016-03-17 | — | — | US | disclosed |
| US-20160075712-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PLEXXIKON INC. | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075712-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP11B2, CYP11B1, CYP2C19 | JAK2 630/4885BRD4 1213/4885CREBBP 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.