Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 4/20 | 0.61 |
| ▸ | PTPRC | P08575 | 1/20 | 0.59 |
| ▸ | BCL2 | P10415 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | PPOX | P50336 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | TGM2 | P21980 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24730389 | 0.96 | BCL2 (0.57) | S100A4PTPRCBCL2MCL1PPOX | |
| SCHEMBL23294517 | 0.92 | S100A4 (0.63) | S100A4PTPRCBCL2MCL1PPOX | |
| SCHEMBL29914626 | 0.92 | S100A4 (0.63) | S100A4PTPRCBCL2MCL1PPOX | |
| SCHEMBL6884062 | 0.92 | BCL2 (0.62) | S100A4PTPRCBCL2MCL1PPOX | |
| SCHEMBL29594014 | 0.87 | S100A4 (0.80) | S100A4PTPRCBCL2MCL1HSP90AA1 | |
| SCHEMBL11876117 | 0.87 | S100A4 (0.80) | S100A4PTPRCPPOXNPC1HSP90AA1 | |
| SCHEMBL597375 | 0.87 | S100A4 (0.80) | S100A4PTPRCBCL2MCL1HSP90AA1 | |
| SCHEMBL29018327 | 0.85 | S100A4 (0.72) | S100A4PTPRCBCL2MCL1NPC1 | |
| SCHEMBL16659000 | 0.82 | S100A4 (0.90) | S100A4PTPRCBCL2MCL1NPC1 | |
| SCHEMBL12469932 | 0.82 | S100A4 (0.71) | S100A4PTPRCBCL2MCL1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954683-B1 | 2-(PHENYL OR HETEROCYCLYL)-1H-PHENANTHRO(9,10-D)IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK CANADA INC (CA) | 2016-03-02 | — | — | EP | disclosed |
| EP-1954683-B1 | 2-(PHENYL OR HETEROCYCLYL)-1H-PHENANTHRO(9,10-D)IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK CANADA INC (CA) | 2016-03-02 | — | — | EP | disclosed |
| EP-1828143-B1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2013-03-20 | — | — | EP | disclosed |
| EP-1954134-B1 | PROCESS FOR SYNTHESIZING A 2-PHENYL-1H-PHENANTRHO[9,10-D]IMIDAZOLE DERIVATIVE | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |
| US-7943649-B2 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-05-17 | — | — | US | disclosed |
| US-7943649-B2 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-05-17 | — | — | US | disclosed |
| US-7943649-B2 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-05-17 | — | — | US | disclosed |
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | MERCK & CO., INC. | 2009-11-19 | — | — | US | disclosed |
| EP-1828143-A4 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-08-26 | — | — | EP | disclosed |
| US-20090203922-A1 | Process for Synthesizing 2-Phenyl-1H-Phenanthro[9,10-d]Imidazole Derivative | MERCK SHARP & DOHME CORP. | 2009-08-13 | — | — | US | disclosed |
| EP-1828143-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007095753-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES | MERCK FROSST CANADA LTD. (CA) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007061853-A2 | PROCESS FOR SYNTHESIZING 2-PHENYL-1H-PHENANTRHO[9,10-D]IMIDAZOLE DERIVATIVE | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007059610-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007059610-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007059611-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007059611-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061849-A2 | METHOD OF GENERATING AMORPHOUS SOLID FOR WATER-INSOLUBLE PHARMACEUTICALS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061849-A2 | METHOD OF GENERATING AMORPHOUS SOLID FOR WATER-INSOLUBLE PHARMACEUTICALS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2006063466-A1 | 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286772-A1 | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles | PTGES, PTGS1, PTGES2 | S100A4 2484/4885PTPRC 2890/4885BCL2 4317/4885 |
| US-20090203922-A1 | Process for Synthesizing 2-Phenyl-1H-Phenanthro[9,10-d]Imidazole Derivative | PTGES, PTGS1, PTGES2 | S100A4 3831/4885PTPRC 4128/4885BCL2 4111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.