Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507614 | 0.82 | PARP1 (1.00) | PARP1CHEK1PIM1RPS6KA3IP6K1 | |
| SCHEMBL29605527 | 0.82 | PARP1 (1.00) | PARP1CHEK1PIM1RPS6KA3IP6K1 | |
| SCHEMBL17586177 | 0.78 | SLC2A1 (0.73) | PARP1CHEK1PIM1IP6K1AKT1 | |
| SCHEMBL17586185 | 0.73 | IP6K1 (0.52) | PARP1CHEK1PIM1IP6K1AKT1 | |
| SCHEMBL17586174 | 0.72 | IP6K1 (0.39) | PARP1CHEK1PIM1IP6K1AKT1 | |
| SCHEMBL30716590 | 0.72 | KDM4E (0.52) | CHEK1 | |
| SCHEMBL17586181 | 0.72 | IP6K1 (0.58) | PARP1CHEK1PIM1IP6K1AKT1 | |
| SCHEMBL17586165 | 0.71 | SLC2A1 (0.46) | PARP1CHEK1PIM1IP6K1AKT1 | |
| SCHEMBL13820309 | 0.71 | PARP1 (0.78) | PARP1CHEK1PIM1RPS6KA3IP6K1 | |
| SCHEMBL17586167 | 0.71 | ALDH1A1 (0.56) | PARP1CHEK1IP6K1SLC2A1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493426-B2 | Quinazolinone derivatives useful as FGFR kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | FGFR1, FGFR3, FGFR2 | PARP1 1343/4885CHEK1 100/4885PIM1 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.