SCHEMBL1758816

SCHEMBL1758816

O=C(Nc1cccnc1)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAAH O00519 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29499690 1.00 FAAH (1.00) FAAH
Hydrochloric Acid SCHEMBL1759222 0.99 FAAH (0.98) FAAH
SCHEMBL896175 0.92 FAAH (1.00) FAAH
SCHEMBL1758812 0.91 FAAH (1.00) FAAH
SCHEMBL897085 0.90 FAAH (1.00) FAAH
SCHEMBL896840 0.90 FAAH (1.00) FAAH
Hydrochloric Acid SCHEMBL1759016 0.90 FAAH (0.98) FAAH
SCHEMBL896835 0.90 FAAH (1.00) FAAH
SCHEMBL896169 0.89 FAAH (1.00) FAAH
SCHEMBL896703 0.89 FAAH (1.00) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120225097-A1 PIPERAZINECARBOXAMIDE DERIVATIVE USEFUL AS A MODULATOR OF FATTY ACID AMIDE HYDROLASE (FAAH) JANSSEN PHARMACEUTICA NV (BE) 2012-09-06 US disclosed
WO-2011060026-A1 PIPERAZINECARBOXAMIDE DERIVATIVE USEFUL AS A MODULATOR OF FATTY ACID AMIDE HYDROLASE (FAAH) JANSEN PHARMACEUTICA NV (BE) 2011-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120225097-A1 PIPERAZINECARBOXAMIDE DERIVATIVE USEFUL AS A MODULATOR OF FATTY ACID AMIDE HYDROLASE (FAAH) FAAH, FAAH2, APEH FAAH 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.