Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239326 | 0.89 | CYP2C9 (0.59) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL29472028 | 0.89 | CYP2C9 (0.59) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL239325 | 0.89 | CYP2C9 (0.59) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL16234584 | 0.83 | CYP2C9 (0.53) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL14404845 | 0.79 | LMNA (0.50) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL17591505 | 0.77 | MEN1 (0.36) | CYP2C9ALDH1A1TDP1SIGMAR1TSHR | |
| SCHEMBL12332461 | 0.77 | CYP2C9 (0.52) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL7091919 | 0.77 | CYP2C9 (0.52) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL21728463 | 0.77 | CYP2C9 (0.52) | LMNAHPGDCYP2C9MAPTALDH1A1 | |
| SCHEMBL17591503 | 0.76 | DHODH (0.44) | LMNAHPGDMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776430-B1 | 2- (1,2,3-TRIAZOL-2-YL) BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL) PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-16 | — | — | EP | disclosed |