SCHEMBL239326

SCHEMBL239326

Cc1ccccc1N=CC=Nc1ccccc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.59
LMNA P02545 6/20 0.58
HPGD P15428 2/20 0.58
ALDH1A1 P00352 7/20 0.48
MAPT P10636 6/20 0.48
KDM4E B2RXH2 3/20 0.48
RECQL P46063 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
POLB P06746 1/20 0.48
MPI P34949 1/20 0.48
HTT P42858 3/20 0.47
TDP1 Q9NUW8 2/20 0.47
GLA P06280 1/20 0.47
GAA P10253 1/20 0.47
THRB P10828 1/20 0.47
TSHR P16473 4/20 0.45
ACHE P22303 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29472028 1.00 CYP2C9 (0.59) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL239325 1.00 CYP2C9 (0.59) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL16234584 0.93 CYP2C9 (0.53) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL17591502 0.89 LMNA (0.50) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL14404845 0.89 LMNA (0.50) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL12332461 0.86 CYP2C9 (0.52) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL7091919 0.86 CYP2C9 (0.52) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL21728463 0.86 CYP2C9 (0.52) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL19625972 0.84 LMNA (0.50) CYP2C9LMNAHPGDALDH1A1MAPT
SCHEMBL12459466 0.82 CYP2C9 (0.57) CYP2C9LMNAHPGDALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1363923-B1 RHODIUM AND IRIDIUM COMPLEXES MERCK PATENT GMBH (DE) 2009-04-01 EP claimed
EP-1562964-B1 PALLADIUM AND PLATINUM COMPLEXES MERCK PATENT GMBH (DE) 2006-07-19 EP claimed
US-20040138455-A1 Rhodium and iridium complexes MERCK PATENT GMBH (DE) 2004-07-15 US claimed
US-12635401-B2 Metal complexes UDC Ireland (IE) 2026-05-19 US disclosed
EP-4069709-B1 METAL COMPLEXES UDC IRELAND LTD (IE) 2025-04-23 EP disclosed
US-12250871-B2 Metal complexes UDC IRELAND LIMITED (IE) 2025-03-11 US disclosed
US-20240260448-A1 Metal Complexes UDC IRELAND LIMITED (IE) 2024-08-01 US disclosed
US-11917901-B2 Metal complexes UDC IRELAND LIMITED (IE) 2024-02-27 US disclosed
US-20230056324-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2023-02-23 US disclosed
US-11404649-B2 Electroluminescent bridged metal complexes for use in electronic devices MERCK PATENT GMBH (DE) 2022-08-02 US disclosed
US-20220209141-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2022-06-30 US disclosed
EP-1944309-A1 Rhodium and iridium complexes Merck Patent GmbH (DE) 2008-07-16 EP disclosed
EP-1558619-B1 RHODIUM AND IRIDIUM COMPLEXES MERCK PATENT GMBH (DE) 2008-03-12 EP disclosed
US-20080027220-A1 Metal Complexes MERCK PATENT GMBH (DE) 2008-01-31 US disclosed
US-7125998-B2 Rhodium and iridium complexes MERCK PATENT GMBH (DE) 2006-10-24 US disclosed
EP-1562964-B1 PALLADIUM AND PLATINUM COMPLEXES MERCK PATENT GMBH (DE) 2006-07-19 EP disclosed
US-20060071206-A1 Palladium and platinum complexes UDC IRELAND LIMITED (IE) 2006-04-06 US disclosed
US-20050253135-A1 Rhodium and iridium complexes MERCK PATENT GMBH (DE) 2005-11-17 US disclosed
US-20050031900-A1 Aromatic monomer-and conjugated polymer-metal complexes SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-10 US disclosed
US-20040138455-A1 Rhodium and iridium complexes MERCK PATENT GMBH (DE) 2004-07-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12635401-B2 Metal complexes SCO2, SOD1, NR4A1 CYP2C9 1408/4885LMNA 556/4885HPGD 3632/4885
US-20040138455-A1 Rhodium and iridium complexes RPIA, MPI, INPP5B CYP2C9 817/4885LMNA 4528/4885HPGD 1683/4885
US-20050253135-A1 Rhodium and iridium complexes RPIA, SIRT5, RAB35 CYP2C9 1431/4885LMNA 4849/4885HPGD 1910/4885
US-12250871-B2 Metal complexes AP1M1, SOD1, AP3M1 CYP2C9 2421/4885LMNA 4288/4885HPGD 3841/4885
US-20230056324-A1 METAL COMPLEXES MCU, IMMT, SOD1 CYP2C9 2879/4885LMNA 4719/4885HPGD 3581/4885
US-11404649-B2 Electroluminescent bridged metal complexes for use in electronic devices MCOLN2, MCOLN1, NCLN CYP2C9 2417/4885LMNA 1174/4885HPGD 1859/4885
US-20080027220-A1 Metal Complexes AP1M1, SOD1, AP1G1 CYP2C9 1200/4885LMNA 4651/4885HPGD 3157/4885
US-20220209141-A1 METAL COMPLEXES AP1M1, SOD1, AP3M1 CYP2C9 2421/4885LMNA 4288/4885HPGD 3841/4885
US-20060071206-A1 Palladium and platinum complexes PMS2, PDCD1, PDCD1LG2 CYP2C9 2381/4885LMNA 4853/4885HPGD 2215/4885
US-11917901-B2 Metal complexes MCOLN2, MCOLN1, AP1M1 CYP2C9 3053/4885LMNA 547/4885HPGD 3283/4885
US-20240260448-A1 Metal Complexes SOD1, AP1M1, AP3M1 CYP2C9 2236/4885LMNA 4436/4885HPGD 3882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.