Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592988 | 0.91 | PHGDH (0.46) | PHGDHGAAMEN1KMT2AMAPK8 | |
| SCHEMBL17592907 | 0.84 | PHGDH (0.43) | PHGDHNPC1RAB9AHPGDMAPK1 | |
| SCHEMBL17592890 | 0.82 | TP53 (0.48) | NPC1RAB9AHPGDMAPK1TP53 | |
| SCHEMBL17592994 | 0.82 | KDM4E (0.40) | PHGDHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17593251 | 0.81 | L3MBTL1 (0.40) | PHGDHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17593076 | 0.80 | NPC1 (0.44) | PHGDHGAAMEN1KMT2ANPC1 | |
| SCHEMBL17593212 | 0.80 | PHGDH (0.66) | PHGDHIDEGAAMEN1KMT2A | |
| SCHEMBL17592998 | 0.80 | PHGDH (0.40) | PHGDHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17593245 | 0.77 | HTR2C (0.47) | NAMPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL17593034 | 0.77 | PHGDH (0.42) | PHGDHMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |