Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592890 | 0.81 | TP53 (0.48) | HTR2CMMP2POLBNPC1RAB9A | |
| SCHEMBL17593119 | 0.76 | GRM4 (0.48) | MEN1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL17592907 | 0.74 | PHGDH (0.43) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL17593076 | 0.74 | NPC1 (0.44) | MEN1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL17593142 | 0.74 | MAPT (0.66) | HTR2CMEN1KMT2AMMP2KDM4E | |
| SCHEMBL17592888 | 0.73 | NPC1 (0.39) | MEN1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL17592994 | 0.73 | KDM4E (0.40) | MEN1KMT2AKDM4EPOLBNPC1 | |
| SCHEMBL17593091 | 0.72 | MAPT (0.49) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL17593251 | 0.72 | L3MBTL1 (0.40) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL17593077 | 0.72 | NPC1 (0.37) | MEN1KMT2AKDM4EPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |