Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.44 |
| ▸ | MGLL | Q99685 | 7/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678831 | 0.81 | SIGMAR1 (0.51) | SIGMAR1MGLLOPRD1POLBMEN1 | |
| SCHEMBL4679033 | 0.78 | GRIN2B (0.52) | SIGMAR1MGLLOPRD1POLBMEN1 | |
| SCHEMBL31024103 | 0.74 | GRIN2B (0.48) | SIGMAR1OPRD1POLB | |
| SCHEMBL15101002 | 0.74 | ABHD6 (0.57) | ABHD6MGLLPLA2G7 | |
| SCHEMBL27801809 | 0.73 | POLB (0.41) | POLBKMT2AGAA | |
| Hydrochloric Acid SCHEMBL18064781 | 0.72 | ABHD6 (0.56) | ABHD6MGLLPLA2G7 | |
| SCHEMBL5932732 | 0.72 | POLB (0.40) | POLBKMT2AGAA | |
| Trifluoroacetic Acid SCHEMBL19260950 | 0.72 | ABHD6 (0.52) | ABHD6MGLLPLA2G7 | |
| Trifluoroacetic Acid SCHEMBL953317 | 0.71 | GAA (0.52) | SIGMAR1MGLLPOLBMEN1KMT2A | |
| SCHEMBL16935385 | 0.71 | ABHD6 (0.42) | ABHD6MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191449-A1 | NOVEL COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016037578-A1 | NOVEL COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-03-17 | — | — | WO | disclosed |