Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.73 |
| ▸ | PTGFR | P43088 | 4/20 | 0.67 |
| ▸ | DHFR | P00374 | 1/20 | 0.65 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793184 | 0.94 | DHODH (0.79) | DHODHDHFRALKBH5 | |
| SCHEMBL8730770 | 0.92 | DHODH (0.81) | DHODHDHFRALKBH5 | |
| SCHEMBL18089100 | 0.90 | PTGFR (0.64) | DHODHPTGFRDHFRALKBH5 | |
| SCHEMBL23590030 | 0.89 | DHODH (0.90) | DHODHDHFRALKBH5 | |
| SCHEMBL29617666 | 0.89 | DHODH (0.90) | DHODHDHFRALKBH5 | |
| SCHEMBL14553160 | 0.88 | DHODH (0.73) | DHODHPTGFR | |
| Hydrochloric Acid SCHEMBL28389865 | 0.86 | DHODH (0.71) | DHODHPTGFR | |
| SCHEMBL2372361 | 0.86 | DHODH (0.74) | DHODHPTGFRAURKAKDRAURKB | |
| SCHEMBL17593932 | 0.86 | PTGFR (0.68) | DHODHPTGFRDHFRALKBH5 | |
| SCHEMBL10580471 | 0.85 | DHODH (0.76) | DHODHPTGFRAURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479765-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-11-19 | — | — | US | disclosed |
| US-10479765-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-11-19 | — | — | US | disclosed |
| US-10189788-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-29 | — | — | US | disclosed |
| US-10189788-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-29 | — | — | US | disclosed |
| US-20190002409-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-03 | — | — | US | disclosed |
| US-20190002409-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-03 | — | — | US | disclosed |
| US-10117864-B2 | Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-06 | — | — | US | disclosed |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-02-08 | — | — | US | disclosed |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-02-08 | — | — | US | disclosed |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-02-08 | — | — | US | disclosed |
| US-20170260140-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma Aktiengesekkschaft (DE) | 2017-09-14 | — | — | US | disclosed |
| US-20170260140-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma Aktiengesekkschaft (DE) | 2017-09-14 | — | — | US | disclosed |
| US-20170260140-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma Aktiengesekkschaft (DE) | 2017-09-14 | — | — | US | disclosed |
| EP-3191452-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Bayer Pharma Aktiengesellschaft (DE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016146602-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-09-22 | — | — | WO | disclosed |
| WO-2016037954-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479765-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | AADAC, NFKBIA, NOD2 | DHODH 1976/4885PTGFR 749/4885DHFR 1184/4885 |
| US-20170260140-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | AADAC, NFKBIA, NOD2 | DHODH 1976/4885PTGFR 749/4885DHFR 1184/4885 |
| US-20190002409-A1 | SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS | AADAC, NFKBIA, NOD2 | DHODH 1976/4885PTGFR 749/4885DHFR 1184/4885 |
| US-10117864-B2 | Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof | AADAC, BRD4, GOT2 | DHODH 2475/4885PTGFR 1602/4885DHFR 1176/4885 |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | AADAC, BRD4, GOT2 | DHODH 2475/4885PTGFR 1602/4885DHFR 1176/4885 |
| US-10189788-B2 | Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents | AADAC, NFKBIA, NOD2 | DHODH 1976/4885PTGFR 749/4885DHFR 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.