Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 3/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL14741065 | 0.90 | L3MBTL1 (0.34) | PDE3BPDE3ACHRM2CHRM1ALDH1A1 | |
| SCHEMBL14758823 | 0.89 | PDE3B (0.34) | PDE3BPDE3AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14745349 | 0.88 | ADK (0.38) | PDE3BPDE3A | |
| SCHEMBL14744863 | 0.77 | HRH3 (0.41) | MAPT | |
| Trifluoroacetic Acid SCHEMBL14745348 | 0.77 | ADK (0.40) | — | |
| SCHEMBL14745225 | 0.77 | PRKD3 (0.44) | PDE3BPDE3AMAPT | |
| SCHEMBL16568097 | 0.77 | KCNH2 (0.33) | ALDH1A1KDM4EMAPT | |
| SCHEMBL14745525 | 0.76 | PDE3B (0.34) | PDE3BPDE3ACHRM4 | |
| SCHEMBL14745785 | 0.76 | CHRM4 (0.36) | PDE3BPDE3ACHRM4CHRM2CHRM1 | |
| SCHEMBL14745048 | 0.75 | CHRM4 (0.35) | PDE3BPDE3ACHRM4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |