Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453090 | 0.88 | ALDH1A1 (0.77) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL6430908 | 0.85 | ALDH1A1 (0.68) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL11360223 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL28394623 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL28570849 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL25247976 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL14720666 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL8407368 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL3582934 | 0.82 | ALDH1A1 (0.68) | ALDH1A1LMNAUSP2POLBHTT | |
| SCHEMBL17595150 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNAUSP2POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191483-B1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | NORTH & SOUTH BROTHER PHARMACY INVESTMENT CO LTD (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-9951010-B2 | Compounds as CRTH2 antagonist and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-04-24 | — | — | US | disclosed |
| CN-105764900-B | CRTH2 agonist compounds and application thereof | 广东东阳光药业有限公司 | 2018-04-03 | — | — | CN | disclosed |
| US-20170267634-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-09-21 | — | — | US | disclosed |
| EP-3191483-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2017-07-19 | — | — | EP | disclosed |
| CN-105764900-A | Compounds as CRTH2 antagonist and uses thereof | 广东东阳光药业有限公司 | 2016-07-13 | — | — | CN | disclosed |
| WO-2016037591-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267634-A1 | COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF | HRH2, PTGDR2, HRH1 | ALDH1A1 1226/4885LMNA 4062/4885USP2 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.