Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949097 | 0.91 | SIGMAR1 (0.49) | SIGMAR1L3MBTL1MT-CO2ALOX5ALDH1A1 | |
| SCHEMBL31045767 | 0.88 | SIGMAR1 (0.44) | SIGMAR1KMT2AL3MBTL1LMNAMT-CO2 | |
| SCHEMBL21308106 | 0.88 | SIGMAR1 (0.44) | SIGMAR1KMT2AL3MBTL1LMNAMT-CO2 | |
| SCHEMBL1631416 | 0.88 | KMT2A (0.46) | SIGMAR1KMT2AL3MBTL1LMNAMT-CO2 | |
| SCHEMBL4870895 | 0.80 | CHRM2 (0.60) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL5728905 | 0.78 | CHRM2 (0.58) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL8187341 | 0.78 | CHRM2 (0.58) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL1723411 | 0.78 | CHRM2 (0.58) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL911191 | 0.78 | KMT2A (0.51) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL12902953 | 0.78 | KMT2A (0.51) | SIGMAR1KMT2AL3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191492-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-3191492-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| US-10150766-B2 | P2X7 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-12-11 | — | — | US | disclosed |
| US-20170342066-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-30 | — | — | US | disclosed |
| US-20170342066-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-30 | — | — | US | disclosed |
| US-20170342066-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-30 | — | — | US | disclosed |
| EP-3191492-A1 | P2X7 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039977-A1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10150766-B2 | P2X7 modulators | P2RX7, P2RX4, P2RX1 | SIGMAR1 956/4885KMT2A 4518/4885L3MBTL1 4865/4885 |
| US-20170342066-A1 | P2X7 MODULATORS | P2RX7, P2RX4, P2RX1 | SIGMAR1 956/4885KMT2A 4518/4885L3MBTL1 4865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.