Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 10/20 | 0.42 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19654572 | 1.00 | IDO1 (0.42) | IDO1TDO2MAPTALDH1A1KDM4E | |
| SCHEMBL17595459 | 1.00 | IDO1 (0.42) | IDO1TDO2MAPTALDH1A1KDM4E | |
| SCHEMBL21118334 | 0.85 | IDO1 (0.47) | IDO1TDO2MAPTHTTGFER | |
| SCHEMBL2520576 | 0.85 | IDO1 (0.47) | IDO1TDO2MAPTHTTGFER | |
| SCHEMBL2520573 | 0.85 | IDO1 (0.47) | IDO1TDO2MAPTHTTGFER | |
| SCHEMBL2518268 | 0.84 | ALDH1A1 (0.46) | IDO1TDO2MAPTALDH1A1HTT | |
| SCHEMBL2518271 | 0.84 | ALDH1A1 (0.46) | IDO1TDO2MAPTALDH1A1HTT | |
| SCHEMBL2519337 | 0.81 | ALDH1A1 (0.46) | IDO1TDO2MAPTALDH1A1HTT | |
| SCHEMBL149780 | 0.81 | IDO1 (0.61) | IDO1TDO2MAPTALDH1A1HTT | |
| SCHEMBL2519338 | 0.81 | ALDH1A1 (0.46) | IDO1TDO2MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183082-B2 | PET probes of radiofluorinated carboximidamides for IDO-targeted imaging | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170340758-A1 | PET PROBES OF RADIOFLUORINATED CARBOXIMIDAMIDES FOR IDO-TARGETED IMAGING | H LEE MOFFITT CANCER CT & RES (US) | 2017-11-30 | — | — | US | disclosed |
| WO-2016040458-A2 | PET PROBES OF RADIOFLUORINATED CARBOXIMIDAMIDES FOR IDO-TARGETED IMAGING | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2016-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183082-B2 | PET probes of radiofluorinated carboximidamides for IDO-targeted imaging | IDO1, IDO2, KMO | IDO1 1/4885TDO2 6/4885MAPT 3402/4885 |
| US-20170340758-A1 | PET PROBES OF RADIOFLUORINATED CARBOXIMIDAMIDES FOR IDO-TARGETED IMAGING | IDO1, IDO2, IDH1 | IDO1 1/4885TDO2 19/4885MAPT 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.