Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595696 | 1.00 | GRM2 (0.38) | GRM2KDM4EP2RX7PIM1GAA | |
| SCHEMBL17595699 | 0.85 | GAA (0.51) | KDM4EP2RX7PIM1GAATSHR | |
| SCHEMBL17595700 | 0.85 | GAA (0.51) | KDM4EP2RX7PIM1GAATSHR | |
| SCHEMBL31177343 | 0.74 | DPP4 (0.33) | — | |
| SCHEMBL17596250 | 0.70 | P2RX7 (0.43) | P2RX7GAATSHR | |
| SCHEMBL17596252 | 0.70 | P2RX7 (0.43) | P2RX7GAATSHR | |
| SCHEMBL17595702 | 0.70 | P2RX7 (0.47) | P2RX7GAATSHR | |
| SCHEMBL17596658 | 0.70 | P2RX7 (0.48) | P2RX7 | |
| SCHEMBL30888482 | 0.70 | TNKS (0.32) | — | |
| SCHEMBL17596463 | 0.68 | P2RX7 (0.52) | P2RX7SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |