Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 9/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687146 | 0.89 | NR4A2 (0.48) | NR4A2CREBBPMAPTALDH1A1 | |
| SCHEMBL6645844 | 0.88 | NR4A2 (0.47) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL10397737 | 0.85 | NR4A2 (0.67) | NR4A2CREBBPMAPTTUBB1KDM4E | |
| SCHEMBL6649574 | 0.84 | NR4A2 (0.43) | NR4A2CREBBPMAPTTUBB1ALDH1A1 | |
| SCHEMBL6647107 | 0.83 | NR4A2 (0.48) | NR4A2CREBBPMAPTKDM4EALDH1A1 | |
| SCHEMBL1696922 | 0.82 | NR4A2 (0.51) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL7360321 | 0.81 | NR4A2 (0.50) | NR4A2CREBBPMAPTTUBB1KIF11 | |
| SCHEMBL5507447 | 0.81 | NR4A2 (0.72) | NR4A2CREBBPMAPTTUBB1ALDH1A1 | |
| SCHEMBL31618837 | 0.81 | NR4A2 (0.56) | NR4A2CREBBPMAPTTUBB1KDM4E | |
| SCHEMBL6511301 | 0.81 | NR4A2 (0.50) | NR4A2CREBBPMAPTTUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665704-A1 | AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES | Galapagos NV (BE) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098033-A1 | AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2012-07-26 | — | — | WO | disclosed |
| WO-2011057959-A1 | INDOLE AND INDAZOLE DERIVATIVES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| EP-1474425-A1 | DEAZAPURINES AND USES THEREOF | Eisai Co. Ltd. (JP) | 2004-11-10 | — | — | EP | disclosed |
| WO-2004063336-A2 | USES OF DEAZAPURINES FOR THE TREATMENT OF REPERFUSION INJURIES, OSTEOPOROSIS AND/OR BONE METASTASIS | EISAI CO. LTD. (JP) | 2004-07-29 | — | — | WO | disclosed |
| WO-2003057696-A1 | DEAZAPURINES AND USES THEREOF | EISAI CO. LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |