Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 9/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007089 | 0.89 | NR4A2 (0.50) | NR4A2CREBBPMAPT | |
| SCHEMBL1696922 | 0.84 | NR4A2 (0.51) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL5631381 | 0.84 | NR4A2 (0.70) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL7360321 | 0.83 | NR4A2 (0.50) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL5507447 | 0.83 | NR4A2 (0.72) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL30009696 | 0.83 | NR4A2 (0.50) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL31618837 | 0.83 | NR4A2 (0.56) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL4780483 | 0.82 | MAPT (0.63) | NR4A2MAPTTUBB1 | |
| SCHEMBL1696867 | 0.81 | TUBB1 (0.50) | NR4A2CREBBPMAPTTUBB1 | |
| SCHEMBL1759575 | 0.81 | NR4A2 (0.48) | NR4A2CREBBPMAPTTUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005429-A1 | CERTAIN HETEROCYCLIC SUBSTITUTED IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES AND METHODS OF INHIBITION OF BRUTON’S TYROSINE KINASE BY SUCH COMPOUNDS | CELLULAR GENOMICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |