Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17582636 | 0.88 | PTGS1 (0.54) | PTGS1RECQLHSD17B10ALDH1A1TSHR | |
| SCHEMBL8783376 | 0.80 | PTGS1 (0.56) | PTGS1RECQLHSD17B10ALDH1A1TSHR | |
| SCHEMBL8784355 | 0.78 | PTGS1 (0.53) | PTGS1TDP1RECQLHSD17B10ALDH1A1 | |
| SCHEMBL17596719 | 0.77 | PTGS1 (0.47) | PTGS1TDP1ALDH1A1MAPTLMNA | |
| SCHEMBL1691731 | 0.76 | PTGS1 (0.52) | PTGS1RECQLHSD17B10ALDH1A1TSHR | |
| SCHEMBL19286604 | 0.76 | TSHR (0.53) | PTGS1RECQLHSD17B10ALDH1A1TSHR | |
| SCHEMBL8783937 | 0.76 | PTGS1 (0.47) | PTGS1RECQLHSD17B10MAPTPOLB | |
| SCHEMBL29355967 | 0.75 | HDAC3 (0.52) | PTGS1TDP1ALDH1A1LMNAPOLB | |
| SCHEMBL17582620 | 0.75 | PTGS1 (0.57) | PTGS1RECQLHSD17B10ALDH1A1TSHR | |
| SCHEMBL27408722 | 0.74 | RECQL (0.60) | TDP1RECQLHSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191491-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038140-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | WO | disclosed |