Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700592 | 0.84 | ALDH1A1 (0.43) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL10066103 | 0.83 | PTGS2 (0.51) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL16579480 | 0.83 | TP53 (0.44) | PTGS1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL8784355 | 0.81 | PTGS1 (0.53) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL8783376 | 0.80 | PTGS1 (0.56) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL1691731 | 0.80 | PTGS1 (0.52) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL20443987 | 0.80 | PTGS1 (0.49) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL17582636 | 0.79 | PTGS1 (0.54) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL17582620 | 0.78 | PTGS1 (0.57) | TSHRHSD17B10PTGS1ALDH1A1HTT | |
| SCHEMBL17582584 | 0.77 | PTGS1 (0.50) | TSHRHSD17B10PTGS1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191491-B1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-04 | — | — | EP | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |