Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178203 | 0.67 | BRD4 (0.38) | MAPTTSHR | |
| SCHEMBL30980046 | 0.67 | NAMPT (0.49) | PDPK1DPP4DPP8NAMPT | |
| SCHEMBL21058321 | 0.67 | MAPT (0.34) | MAPTTSHR | |
| SCHEMBL28912802 | 0.67 | MAPT (0.34) | MAPTTSHR | |
| SCHEMBL20820009 | 0.66 | — | — | |
| SCHEMBL20820011 | 0.66 | — | — | |
| SCHEMBL28702632 | 0.66 | GRM5 (0.33) | MAPTTSHR | |
| SCHEMBL28556462 | 0.66 | GRM5 (0.35) | MAPTTSHR | |
| SCHEMBL17338866 | 0.65 | PDPK1 (0.41) | PDPK1 | |
| SCHEMBL29942704 | 0.64 | TSHR (0.54) | MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191488-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | Janssen Pharmaceutica, N.V. (BE) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016039983-A1 | P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |