Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599481 | 0.90 | KEAP1 (0.50) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599524 | 0.82 | MEN1 (0.49) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599544 | 0.73 | KDM4E (0.45) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599488 | 0.73 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599417 | 0.73 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599434 | 0.73 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599477 | 0.72 | KEAP1 (0.59) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599442 | 0.72 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL29584677 | 0.72 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599452 | 0.72 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |