Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 9/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599540 | 0.84 | KEAP1 (0.50) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17614106 | 0.84 | KEAP1 (0.50) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599417 | 0.75 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599434 | 0.75 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599488 | 0.75 | KEAP1 (0.89) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599452 | 0.74 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599442 | 0.74 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL29584677 | 0.74 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17599491 | 0.74 | KEAP1 (1.00) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17614083 | 0.73 | KEAP1 (0.41) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |