Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599550 | 1.00 | KEAP1 (0.41) | KEAP1NFE2L2TSHRNPSR1ALDH1A1 | |
| SCHEMBL17614106 | 0.89 | KEAP1 (0.50) | KEAP1NFE2L2TSHRNPSR1ALDH1A1 | |
| SCHEMBL17599540 | 0.89 | KEAP1 (0.50) | KEAP1NFE2L2TSHRNPSR1ALDH1A1 | |
| SCHEMBL17599548 | 0.76 | NPSR1 (0.53) | KEAP1NFE2L2TSHRNPSR1ALDH1A1 | |
| SCHEMBL17599551 | 0.76 | SLC6A2 (0.43) | KEAP1NFE2L2TSHRALDH1A1KDM4E | |
| SCHEMBL17599477 | 0.73 | KEAP1 (0.59) | KEAP1NFE2L2TSHRNPSR1ALDH1A1 | |
| SCHEMBL2508849 | 0.73 | ATM (0.47) | TSHRNPSR1ALDH1A1KDM4EKMT2A | |
| SCHEMBL2508847 | 0.73 | ATM (0.47) | TSHRNPSR1ALDH1A1KDM4EKMT2A | |
| SCHEMBL17599527 | 0.70 | SLC6A3 (0.53) | KEAP1NFE2L2ALDH1A1KDM4EKMT2A | |
| SCHEMBL2506784 | 0.70 | KDM4E (0.49) | TSHRALDH1A1KDM4EKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |