Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1234104 | 0.84 | NPSR1 (0.45) | USP30ALDH1A1DGAT1HPGDTSHR | |
| SCHEMBL12784906 | 0.81 | USP30 (0.41) | USP30AAK1PRMT5WDR77BACE1 | |
| SCHEMBL13053330 | 0.80 | HDAC3 (0.48) | ALDH1A1HPGDTSHRMAPK1ATM | |
| SCHEMBL12785064 | 0.79 | LMNA (0.41) | USP30ALDH1A1HPGDTSHRL3MBTL1 | |
| SCHEMBL823673 | 0.79 | DAO (0.44) | USP30HPGDL3MBTL1 | |
| SCHEMBL1475922 | 0.77 | F2 (0.43) | USP30F2F11PRSS1PRSS2 | |
| SCHEMBL29092872 | 0.77 | USP30 (0.36) | USP30DGAT1F2F11PRSS1 | |
| SCHEMBL4959846 | 0.76 | TSHR (0.32) | USP30TSHR | |
| SCHEMBL12784878 | 0.76 | PRMT5 (0.49) | USP30AAK1PRMT5WDR77BACE1 | |
| SCHEMBL8549434 | 0.76 | TSHR (0.44) | ALDH1A1HPGDTSHRMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |