Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 8/20 | 0.70 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599422 | 1.00 | KEAP1 (0.70) | KEAP1NFE2L2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17599511 | 0.90 | KEAP1 (0.71) | KEAP1NFE2L2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17599512 | 0.90 | KEAP1 (0.71) | KEAP1NFE2L2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17599437 | 0.85 | KEAP1 (0.64) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599427 | 0.85 | KEAP1 (0.71) | KEAP1NFE2L2NOTUM | |
| SCHEMBL24812743 | 0.85 | KEAP1 (0.87) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612896 | 0.83 | KEAP1 (0.62) | KEAP1NFE2L2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17599508 | 0.83 | KEAP1 (0.62) | KEAP1NFE2L2LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL17599452 | 0.82 | KEAP1 (1.00) | KEAP1NFE2L2LMNANOTUMKDM4E | |
| SCHEMBL17599442 | 0.82 | KEAP1 (1.00) | KEAP1NFE2L2LMNANOTUMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |