Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 9/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612896 | 1.00 | KEAP1 (0.62) | KEAP1NFE2L2NOTUMKCNH2LMNA | |
| SCHEMBL17599464 | 0.90 | KEAP1 (0.66) | KEAP1NFE2L2NOTUMSMN1; SMN2 | |
| SCHEMBL17599512 | 0.86 | KEAP1 (0.71) | KEAP1NFE2L2NOTUMLMNAMAPK1 | |
| SCHEMBL17599511 | 0.86 | KEAP1 (0.71) | KEAP1NFE2L2NOTUMLMNAMAPK1 | |
| SCHEMBL17599422 | 0.83 | KEAP1 (0.70) | KEAP1NFE2L2NOTUMLMNAMAPK1 | |
| SCHEMBL17599484 | 0.83 | KEAP1 (0.70) | KEAP1NFE2L2NOTUMLMNAMAPK1 | |
| SCHEMBL17612856 | 0.83 | KEAP1 (0.56) | KEAP1NFE2L2MAPK1SMN1; SMN2POLB | |
| SCHEMBL17599427 | 0.81 | KEAP1 (0.71) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612871 | 0.81 | KEAP1 (0.59) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17599475 | 0.81 | KEAP1 (0.59) | KEAP1NFE2L2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |