Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 5/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599467 | 0.89 | KMT2A (0.55) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599429 | 0.88 | KMT2A (0.51) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599466 | 0.88 | KMT2A (0.51) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599431 | 0.87 | KMT2A (0.50) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599433 | 0.85 | KMT2A (0.48) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599435 | 0.83 | ALDH1A1 (0.57) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599329 | 0.83 | KMT2A (0.55) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599423 | 0.82 | ALDH1A1 (0.56) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599483 | 0.82 | MEN1 (0.56) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599463 | 0.80 | ALDH1A1 (0.57) | KMT2AKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998295-A1 | Aryl substituted naphthyl sulfonamide derivatives as keap-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |