Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599545 | 0.87 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599536 | 0.83 | KDM4E (0.47) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599525 | 0.82 | KMT2A (0.51) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599543 | 0.76 | KDM4E (0.43) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599538 | 0.75 | KDM4E (0.53) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599535 | 0.75 | KDM4E (0.53) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599430 | 0.74 | KMT2A (0.51) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599467 | 0.74 | KMT2A (0.55) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599552 | 0.73 | KDM4E (0.47) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL17599510 | 0.72 | KMT2A (0.53) | ALDH1A1HPGDKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |