Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.73 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.73 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599450 | 0.94 | KEAP1 (0.66) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599442 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL29584677 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599452 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599491 | 0.85 | KEAP1 (1.00) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599548 | 0.84 | NPSR1 (0.53) | KEAP1NFE2L2KDM4EMEN1ALDH1A1 | |
| SCHEMBL17599553 | 0.80 | KEAP1 (0.49) | KEAP1NFE2L2KDM4EMEN1ALDH1A1 | |
| SCHEMBL24811433 | 0.80 | KEAP1 (0.89) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599488 | 0.79 | KEAP1 (0.89) | KEAP1NFE2L2NOTUMKDM4EMEN1 | |
| SCHEMBL17599417 | 0.79 | KEAP1 (0.89) | KEAP1NFE2L2NOTUMKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |