Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599450 | 0.90 | KEAP1 (0.66) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17599447 | 0.86 | KEAP1 (0.71) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17612852 | 0.86 | KEAP1 (0.71) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17612859 | 0.86 | KEAP1 (0.71) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17599530 | 0.84 | KEAP1 (0.73) | KEAP1NFE2L2ALDH1A1KMT2AMEN1 | |
| SCHEMBL17599445 | 0.79 | ALDH1A1 (0.55) | NPSR1TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL17599436 | 0.79 | KEAP1 (0.74) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17614083 | 0.76 | KEAP1 (0.41) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17599550 | 0.76 | KEAP1 (0.41) | NPSR1TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL17599553 | 0.76 | KEAP1 (0.49) | TSHRKEAP1NFE2L2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |