Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599554 | 1.00 | KMT2A (0.45) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599535 | 0.85 | KDM4E (0.53) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599538 | 0.85 | KDM4E (0.53) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599542 | 0.83 | KEAP1 (0.48) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599541 | 0.83 | KEAP1 (0.48) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17614108 | 0.80 | KMT2A (0.34) | KMT2AKDM4EMEN1L3MBTL1LMNA | |
| SCHEMBL17599545 | 0.75 | ALDH1A1 (0.47) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599472 | 0.74 | ALDH1A1 (0.41) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17159202 | 0.73 | KDM4E (0.44) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17159204 | 0.73 | KDM4E (0.44) | KMT2AKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |