Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589617 | 0.95 | KDM4E (0.53) | KDM4EALDH1A1HPGDPDE4DHDAC4 | |
| SCHEMBL7712341 | 0.95 | KDM4E (0.56) | KDM4EALDH1A1HPGDPDE4DHDAC4 | |
| SCHEMBL2584849 | 0.92 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDPDE4DMEN1 | |
| SCHEMBL2594350 | 0.91 | KDM4E (0.48) | KDM4EALDH1A1HPGDPDE4DMEN1 | |
| SCHEMBL2591692 | 0.90 | KDM4E (0.47) | KDM4EALDH1A1HPGDPDE4DMEN1 | |
| SCHEMBL2584958 | 0.89 | KDM4E (0.46) | KDM4EALDH1A1HPGDPDE4DMEN1 | |
| SCHEMBL2588925 | 0.89 | KDM4E (0.50) | KDM4EALDH1A1HPGDPDE4DHDAC4 | |
| SCHEMBL14736996 | 0.88 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDPDE4DHDAC4 | |
| SCHEMBL2591894 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1HPGDPDE4DMEN1 | |
| SCHEMBL2589425 | 0.84 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDPDE4DHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |