Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737583 | 0.88 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL14734816 | 0.86 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL14735746 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2591199 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL17599573 | 0.84 | KDM4E (0.56) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2594223 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2587488 | 0.84 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2592948 | 0.83 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2591567 | 0.83 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL2590015 | 0.83 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-B1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-03-23 | — | — | EP | disclosed |
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |