Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.34 |
| ▸ | CA2 | P00918 | 5/20 | 0.34 |
| ▸ | CA9 | Q16790 | 5/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL497343 | 0.91 | MEN1 (0.55) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL10924191 | 0.91 | MEN1 (0.55) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL28958108 | 0.91 | MEN1 (0.55) | HTTMEN1THRBKMT2AMAPT | |
| Sulfuric Acid SCHEMBL9773608 | 0.88 | MEN1 (0.52) | HTTMEN1THRBKMT2AMAPT | |
| Sulfuric Acid SCHEMBL10924188 | 0.88 | MEN1 (0.52) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL5962250 | 0.88 | MEN1 (0.52) | HTTMEN1THRBKMT2AMAPT | |
| Sulfuric Acid SCHEMBL1490955 | 0.88 | MEN1 (0.52) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL17599676 | 0.85 | USP2 (0.37) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL27497348 | 0.82 | MEN1 (0.65) | HTTMEN1THRBKMT2AMAPT | |
| Trolamine SCHEMBL3690709 | 0.82 | MEN1 (0.65) | HTTMEN1THRBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632427-B1 | OPHTHALMIC COMPOSITIONS CONTAINING PROSTAGLANDINS | OMNIVISION GMBH (DE) | 2016-03-23 | — | — | EP | disclosed |