Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 8/20 | 0.38 |
| ▸ | CA2 | P00918 | 8/20 | 0.38 |
| ▸ | CA9 | Q16790 | 7/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL497343 | 0.97 | MEN1 (0.55) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL10924191 | 0.97 | MEN1 (0.55) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL28958108 | 0.97 | MEN1 (0.55) | MEN1THRBHTTKMT2AMAPT | |
| Sulfuric Acid SCHEMBL1490955 | 0.93 | MEN1 (0.52) | MEN1THRBHTTKMT2AMAPT | |
| Sulfuric Acid SCHEMBL10924188 | 0.93 | MEN1 (0.52) | MEN1THRBHTTKMT2AMAPT | |
| Sulfuric Acid SCHEMBL9773608 | 0.93 | MEN1 (0.52) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL17599677 | 0.88 | HTT (0.46) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL3690709 | 0.88 | MEN1 (0.65) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL27497348 | 0.88 | MEN1 (0.65) | MEN1THRBHTTKMT2AMAPT | |
| Trolamine SCHEMBL8858341 | 0.86 | MEN1 (0.51) | MEN1THRBHTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8083339-B2 | Ink set, treating liquid, recording liquid, image recording apparatus and image recording method | RICOH COMPANY, LTD. (JP) | 2011-12-27 | — | — | US | disclosed |
| US-20060203056-A1 | Ink set, treating liquid, recording liquid, image recording apparatus and image recording method | RICOH COMPANY, LTD. (JP) | 2006-09-14 | — | — | US | disclosed |
| EP-1682355-A1 | INK SET, TREATING LIQUID, RECORDING LIQUID, IMAGE RECORDING APPARATUS AND IMAGE RECORDING METHOD | Ricoh Company, Ltd. (JP) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044574-A1 | INK SET, TREATING LIQUID, RECORDING LIQUID, IMAGE RECORDING APPARATUS AND IMAGE RECORDING METHOD | RICOH COMPANY, LTD. (JP) | 2005-05-19 | — | — | WO | disclosed |