Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 11/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17600659 | 0.89 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL17600661 | 0.87 | ALOX15 (0.57) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL19320610 | 0.83 | KDM4E (0.64) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL17600647 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL385458 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL6923876 | 0.81 | KDM4E (0.69) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL17616303 | 0.78 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDRAB9AALOX15 | |
| SCHEMBL14829878 | 0.77 | GAA (0.51) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL21430761 | 0.76 | GAA (0.55) | ALDH1A1KDM4EHPGDNPC1MAPT | |
| SCHEMBL6924089 | 0.74 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963466-B2 | Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2018-05-08 | — | — | US | disclosed |
| US-9963466-B2 | Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170253617-A1 | Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists | VANDERBILT UNIVERSITY | 2017-09-07 | — | — | US | disclosed |
| US-20170253617-A1 | Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists | VANDERBILT UNIVERSITY | 2017-09-07 | — | — | US | disclosed |
| US-9572794-B2 | Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists | VANDERBILT UNIVERSITY (US) | 2017-02-21 | — | — | US | disclosed |
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253617-A1 | Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists | F2RL3, F2R, F2RL1 | ALDH1A1 3877/4885KDM4E 1291/4885HPGD 843/4885 |
| US-20160083363-A1 | Substituted Indoles as Selective Protease Activated Receptor 4 (PAR-4) Antagonists | F2RL3, F2R, F2RL1 | ALDH1A1 3242/4885KDM4E 962/4885HPGD 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.