Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | VNN1 | O95497 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | FAP | Q12884 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17600733 | 1.00 | ALDH1A1 (0.52) | ALDH1A1VNN1KDM4EDPP4PREP | |
| SCHEMBL30589318 | 1.00 | ALDH1A1 (0.52) | ALDH1A1VNN1KDM4EDPP4PREP | |
| SCHEMBL17600743 | 0.96 | DPP4 (0.52) | ALDH1A1VNN1DPP4PREPFAP | |
| SCHEMBL17600745 | 0.96 | DPP4 (0.52) | ALDH1A1VNN1DPP4PREPFAP | |
| SCHEMBL17600741 | 0.83 | SPHK2 (0.59) | HPGDGAAMEN1KMT2ANPC1 | |
| SCHEMBL17600738 | 0.83 | SPHK2 (0.59) | HPGDGAAMEN1KMT2ANPC1 | |
| SCHEMBL17600723 | 0.81 | GRM5 (0.55) | VNN1CNR2HPGDGAA | |
| SCHEMBL17600726 | 0.81 | GRM5 (0.55) | VNN1CNR2HPGDGAA | |
| SCHEMBL7592715 | 0.80 | ALDH1A1 (0.61) | ALDH1A1VNN1CNR2HTTTDP1 | |
| SCHEMBL27411313 | 0.80 | PIK3CD (0.43) | ALDH1A1KDM4EHPGDPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| EP-2970196-B1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS INC (US) | 2020-11-25 | — | — | EP | disclosed |
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20190300477-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-10-03 | — | — | US | disclosed |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20190010121-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOBLOGIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-01-10 | — | — | US | disclosed |
| US-20160083343-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | Global Blood Therapeutics, Inc (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083343-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | Global Blood Therapeutics, Inc (US) | 2016-03-24 | — | — | US | disclosed |
| US-20160083343-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | Global Blood Therapeutics, Inc (US) | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | HBG2, HBG1, HBB | ALDH1A1 1067/4885VNN1 2124/4885KDM4E 1857/4885 |
| US-20160083343-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | ALDH1A1 1089/4885VNN1 2317/4885KDM4E 1701/4885 |
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | HBG2, HBG1, HBB | ALDH1A1 1089/4885VNN1 2317/4885KDM4E 1701/4885 |
| US-20190300477-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | ALDH1A1 1067/4885VNN1 2124/4885KDM4E 1857/4885 |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | ALDH1A1 1089/4885VNN1 2317/4885KDM4E 1701/4885 |
| US-20190010121-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOBLOGIN | HBG2, HBG1, HBB | ALDH1A1 1507/4885VNN1 790/4885KDM4E 2946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.