Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604533 | 0.91 | PHF8 (0.42) | PHF8KDM2BKDM4CKDM5AMAPK14 | |
| SCHEMBL17604551 | 0.84 | PHF8 (0.59) | PHF8KDM2BKDM4CKDM5ASYK | |
| SCHEMBL17604559 | 0.75 | PHF8 (0.60) | PHF8KDM2BKDM4CKDM5A | |
| SCHEMBL17604576 | 0.74 | KDM4C (0.47) | PHF8KDM2BKDM4CKDM5AMAPK14 | |
| SCHEMBL16095130 | 0.73 | KDM4C (0.69) | PHF8KDM2BKDM4CKDM5A | |
| SCHEMBL17604535 | 0.72 | KDM4C (0.46) | PHF8KDM2BKDM4CKDM5AMAPK14 | |
| SCHEMBL16095596 | 0.71 | KDM4C (0.65) | PHF8KDM2BKDM4CKDM5AMAPK14 | |
| SCHEMBL17686559 | 0.64 | KDM2B (0.63) | PHF8KDM2BKDM4CKDM5ACCNT1 | |
| SCHEMBL17604517 | 0.64 | KDM2B (0.65) | PHF8KDM2BKDM4CKDM5ACCNT1 | |
| SCHEMBL17621656 | 0.63 | KDM2B (0.64) | PHF8KDM2BKDM4CKDM5ACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |